Single nucleotide polymorphisms of complement component 5 and periodontitis

BACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.postprin

Genetic polymorphisms and periodontitis in Hong Kong Chinese

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Path-Based Epidemic Spreading in Networks

Conventional epidemic models assume omni-directional contact-based infection. This strongly associates the epidemic spreading process with node degrees. The role of the infection transmission medium is often neglected. In real-world networks, however, the infectious agent as the physical contagion medium usually flows from one node to another via specific directed routes (path-based infection). Here, we use continuous-time Markov chain analysis to model the influence of the infectious agent and routing paths on the spreading behavior by taking into account the state transitions of each node individually, rather than the mean aggregated behavior of all nodes. By applying a mean field approximation, the analysis complexity of the path-based infection mechanics is reduced from exponential to polynomial. We show that the structure of the topology plays a secondary role in determining the size of the epidemic. Instead, it is the routing algorithm and traffic intensity that determine the survivability and the steady-state of the epidemic. We define an infection characterization matrix that encodes both the routing and the traffic information. Based on this, we derive the critical path-based epidemic threshold below which the epidemic will die off, as well as conditional bounds of this threshold which network operators may use to promote/suppress path-based spreading in their networks. Finally, besides artificially generated random and scale-free graphs, we also use real-world networks and traffic, as case studies, in order to compare the behaviors of contact- and path-based epidemics. Our results further corroborate the recent empirical observations that epidemics in communication networks are highly persistent

Resilience of Interdependent Communication and Power Distribution Networks against Cascading Failures

The operations of many modern cyber-physical systems, such as smart grids, are based on increasingly interdependent networks. The impact of cascading failures on such networks has recently received significant attention due to the corresponding effect of these failures on the society. In this paper, we conduct an empirical study on the robustness of interdependent systems formed by the coupling of power grids and communication networks by putting real distribution power grids to the test. We focus on the assessment of the robustness of a large set of medium-voltage (MV) distribution grids, currently operating live in the Netherlands, against cascading failures initiated by different types of faults / attacks. We consider both unintentional random failures and malicious targeted attacks which gradually degrade the capability of the entire system and we evaluate their respective consequences. Our study shows that current MV grids are highly vulnerable to such cascades of failures. Furthermore, we discover that a small-world communication network structure lends itself to the robustness of the interdependent system. Also interestingly enough, we discover that the formation of hub hierarchies, which is known to enhance independent network robustness, actually has detrimental effects against cascading failures. Based on real MV grid topologies, our study yields realistic insights which can be employed as a set of practical guidelines for distribution system operators (DSOs) to design effective grid protection schemes

Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese

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Seamless Support of Low Latency Mobile Applications with NFV-Enabled Mobile Edge-Cloud

Emerging mobile multimedia applications, such as augmented reality, have stringent latency requirements and high computational cost. To address this, mobile edge-cloud (MEC) has been proposed as an approach to bring resources closer to users. Recently, in contrast to conventional fixed cloud locations, the advent of network function virtualization (NFV) has, with some added cost due to the necessary decentralization, enhanced MEC with new flexibility in placing MEC services to any nodes capable of virtualizing their resources. In this work, we address the question on how to optimally place resources among NFV-enabled nodes to support mobile multimedia applications with low latency requirement and when to adapt the current resource placements to address workload changes. We first show that the placement optimization problem is NP-hard and propose an online dynamic resource allocation scheme that consists of an adaptive greedy heuristic algorithm and a detection mechanism to identify the time when the system will no longer be able to satisfy the applications' delay requirement. Our scheme takes into account the effect of current existing techniques (i.e., auto-scaling and load balancing). We design and implement a realistic NFV-enabled MEC simulated framework and show through extensive simulations that our proposal always manages to allocate sufficient resources on time to guarantee continuous satisfaction of the application latency requirements under changing workload while incurring up to 40% less cost in comparison to existing overprovisioning approaches

Low Latency Communication Infrastructure for Synchrophasor Applications in Distribution Networks

With the introduction of new power sources, such as distributed renewable energy resources, and loads, such as electric vehicles, electrical distribution networks must accommodate new energy flow patterns in a considerably dynamic environment. This leads to the need for increasing the observability of the grid to enable a series of mission-critical applications such as voltage/congestion control and fault detection/location. The deployment of Phasor Measurement Units appears to be a promising approach, offering high precision grid monitoring. However, while the low delay requirements of such applications raise a significant challenge to the communication infrastructure, there is currently no clear vision on the exact communication technologies and network topologies that could support these requirements. In this paper, we address this challenge by taking a systematic approach on the design of low latency communication infrastructures. Based on a large set of real medium voltage grid topologies from a European distribution network, we first perform a detailed analysis of the communication requirements. Guided by this analysis, we then propose two algorithms, PLeC and BW-PLeC algorithms, for the design of low latency communication infrastructures that enhance the currently available power-line communication technology with newer high-speed communication links at strategic points in the grid to satisfy the delay requirements while reducing deployment costs

Curling: Content-ubiquitous resolution and delivery infrastructure for next-generation services

CURLING, a Content-Ubiquitous Resolution and Delivery Infrastructure for Next Generation Services, aims to enable a future content-centric Internet that will overcome the current intrinsic constraints by efficiently diffusing media content of massive scale. It entails a holistic approach, supporting content manipulation capabilities that encompass the entire content life cycle, from content publication to content resolution and, finally, to content delivery. CURLING provides to both content providers and customers high flexibility in expressing their location preferences when publishing and requesting content, respectively, thanks to the proposed scoping and filtering functions. Content manipulation operations can be driven by a variety of factors, including business relationships between ISPs, local ISP policies, and specific content provider and customer preferences. Content resolution is also natively coupled with optimized content routing techniques that enable efficient unicast and multicast-based content delivery across the global Internet

QoSatAr: a cross-layer architecture for E2E QoS provisioning over DVB-S2 broadband satellite systems

This article presents QoSatAr, a cross-layer architecture developed to provide end-to-end quality of service (QoS) guarantees for Internet protocol (IP) traffic over the Digital Video Broadcasting-Second generation (DVB-S2) satellite systems. The architecture design is based on a cross-layer optimization between the physical layer and the network layer to provide QoS provisioning based on the bandwidth availability present in the DVB-S2 satellite channel. Our design is developed at the satellite-independent layers, being in compliance with the ETSI-BSM-QoS standards. The architecture is set up inside the gateway, it includes a Re-Queuing Mechanism (RQM) to enhance the goodput of the EF and AF traffic classes and an adaptive IP scheduler to guarantee the high-priority traffic classes taking into account the channel conditions affected by rain events. One of the most important aspect of the architecture design is that QoSatAr is able to guarantee the QoS requirements for specific traffic flows considering a single parameter: the bandwidth availability which is set at the physical layer (considering adaptive code and modulation adaptation) and sent to the network layer by means of a cross-layer optimization. The architecture has been evaluated using the NS-2 simulator. In this article, we present evaluation metrics, extensive simulations results and conclusions about the performance of the proposed QoSatAr when it is evaluated over a DVB-S2 satellite scenario. The key results show that the implementation of this architecture enables to keep control of the satellite system load while guaranteeing the QoS levels for the high-priority traffic classes even when bandwidth variations due to rain events are experienced. Moreover, using the RQM mechanism the user’s quality of experience is improved while keeping lower delay and jitter values for the high-priority traffic classes. In particular, the AF goodput is enhanced around 33% over the drop tail scheme (on average)